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工业用蒽油对小鼠免疫功能影响的研究

The Influence on Mouse Immunologic Function by Industrial Anthracene

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【作者】 杨红田世兰高锦伍韩小兵邵蔚罗成珠吴沁

【Author】 YANG Hong,TIAN Shi lan,GAO Jin wu,HAN Xiao bing, SHAO Wei,LUO Cheng zhu,WU Qin (Department of Preventive Medicine,Nanjing Railway Medical College,Nanjing 210009,China)

【机构】 南京铁道医学院公共卫生学院!江苏南京210009南?

【摘要】 目的 :为评价工业用蒽油对机体免疫功能的影响提供实验依据。方法 :小鼠经消化道用工业用蒽油染毒 2周 ,实验分设高、中、低 3个剂量组和 1个对照组 ,分别检测小鼠外周血T淋巴细胞的酸性α醋萘酚酯酶 (ANAE)阳性率、淋巴细胞增殖功能及腹腔巨噬细胞的吞噬功能。结果 :染毒剂量组外周血T淋巴细胞、淋巴细胞的OD值低于对照组 ,差异显著 (P <0 .0 5 ) ;染毒组的巨噬细胞吞噬率和吞噬指数低于对照组 ,差异不显著 (P >0 .0 5 )。结论 :工业用蒽油对小鼠外周血T淋巴细胞的ANAE阳性率、淋巴细胞增殖具有一定的免疫毒性作用 ,对腹腔巨噬细胞吞噬功能的影响有待进一步研究

【Abstract】 Objective The purpose of this study was to provide an experimental data on the immunotoxicity of industrial anthracene to mouse.Method The animals were divided into 4 groups:a high ,moderate and low dose group,and a control group.The total rate of T lymphocytes in periphral blood,the proliferating ability of lymphocytes in spleen,and phagocytic rate and index of macrophages in abdominal cavity of the animal were detected after exposure to industrial anthracene for 2 weeks through disgestive tract.Results The total rate of T lymphocytes in periphral blood and an inhibited proliferation of lymphocytes in the exposes groups decreased significantly( P <0.05).The phagocitic rate and index in the exposed groups were lower than those of control groups but no statistic significance was found( P >0.05).Conclusion Industrial anthracene can cause cell toxicity on lymphocytes.These results seem to indicate that industrial anthracene may possess potential hazard to the health of the exposed animal.

【关键词】 工业用蒽油淋巴细胞免疫毒性小鼠
【Key words】 industrial anthracenelymphocytesimmunotoxicitymouse
  • 【文献出处】 南京铁道医学院学报 ,JOURNAL OF NANJING RAILWAY MEDICAL COLLEGE , 编辑部邮箱 ,2000年03期
  • 【分类号】R114
  • 【下载频次】19
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