【摘要】 通过不同治疗方案观察阿昔洛韦对慢性乙型肝炎的治疗作用 ,并评价其有效性和安全性。方法　 460例慢性乙型肝炎患者随机分为高、中、低三个剂量组。低剂量组加聚肌胞 ,疗程 2个月 ,随访 3个月～ 1年。观察治疗前后患者的肝、肾功能、HBVM及血尿常规、临床表现及不良反应。结果　 HBe Ag、HBV-DNA阴转率分别为 40 %～ 60 %、43 %～ 66% ,AL T复常率为 60 %～ 65 % ,停药后 3个月～ 1年内无变化。结论　阿昔洛韦疗效稳定 ,中剂量即可取得满意疗效 ,不良反应少而轻 ,未发现严重毒副作用。更多还原

【Abstract】 Purpose To observe the effect of Aciclovir on chronical B virus hepatitis,and assess its efficience and safety.Methods 460 cases of chronical B rirus hepatitis were randomly divided into high,middle and low dose groups,adding polyinosinic polycytidylic acid to low group.They were treated two months and followed up three months to one year.The function of liver and kidney,HBVM,routine of blood and urine were examined.Clinical demonstration and adverse effects were observed.Results The negative rate of HBeAg and HBV DNA were respectively 40%~60% and 43%~66%.The rate of resuming of ALT was 60%~65%.There was no change after three months to one year.Conclusions The effect of Aciclovir was steady.Middle dose can abtain satisfactory effect.The adverse effect was 1ess and slighter.No severe poison effect was discoveried.更多还原