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“消癃通闭”对犬大脑皮层α₁肾上腺素受体的拮抗作用

Antagonism of XLTB on a1-adrenalin Receptor in Canine Cerebral Cortex

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【Author】 Jia Jinming, Sun Limin, Ma Chuntao, et al(Department of Urology, Guanganmen Hospital, Academy of Traditional Chinese Mdeicing, Beijing 100053)

【机构】中国中医研究院广安门医院；北京医科大学；北京医科大学 100053； 100053； 100053；

【摘要】不同浓度的“消癃通闭”浸出液与犬大脑皮层粗制膜及IBE¹²⁵作用,测定“消癃通闭”对IBE¹²⁵与犬大脑皮层α₁-AR结合的抑制作用。结果显示“消癃通闭”对IBE¹²⁵犬大脑皮层的结合呈竞争性拮抗作用,IC₅₀为34.0±6.0g/L,Hill系数为0.70±0.06。佐证本方剂具有α₁-AR拮抗作用。更多还原

【Abstract】 The inhibition of XLTB(Xiao-Long-Tong-Bi) on the combination between 125IBE and a1-a-drenalin receptor (a1-AR) in canine cerebral cortex was studied. Results: The competitive antagonism of XLTB on combination on 125IBE and α1-AR in canine cerebral cortex was showed. IC50 was 34. 0±6.0g/L. Hill coefficient was 0. 70±0. 06. The antagonism of XLTB on α1-AR was proved.更多还原