【摘要】 目的　研究胃切除术后胆汁细菌变化与胆石形成之间的关系。方法　将杂种雄犬随机分为对照组 (6条 ,行剖腹探查术 ) ,B- 组 (6条 ,行胃大部切除 Billroth- 式胃肠重建术 ) ,B- 组 (6条 ,行胃大部切除 Billroth- 式胃肠重建术 )。应用日立 70 70生化自动分析仪 ,观察 3组动物胆汁成分的变化 ,并用 ABR- ID- 2 2 A及 ABR- ID- 10系统进行胆汁的细菌鉴定。结果　 3组动物肝功能、胆汁胆固醇 (cholesterol,CHO)、总胆红素 (totalbilirubin,TBIL )、磷脂 (phosphatide,PL)均无明显改变 (P>0 .0 1)。 B- 组及 B- 组较对照组 ,胆囊内压明显下降 (P<0 .0 1) ,胆囊容积明显增大 (P<0 .0 1) ,总胆汁酸 (TBA)显著下降 (P<0 .0 1) ,并有需氧菌及厌氧菌的混合感染 ,B- 组有 2条犬形成胆色素类结石。结论　胃切除术后胆石症的发生与迷走神经切断及胆汁细菌感染有关更多还原

【Abstract】 Objective To explore relationship between the change of bacteria in bile and gallstone formation following gastrectomy.Method To inspect the change of biliary portion and identify the bacteria in bile on animals.Result Billroth Ⅰgroup and Billroth Ⅱgroup compared with the opposition,the pressure decreased,the cholecystic volume increased significantly and the concentration of total bile acid decreased significantly(P<0.01).Biliary calculi was found in the gallbladders of two experimental animals in the Billroth Ⅱgroup and there was bacterial infection.Conclusion This study infers that the formation of gallstone following gastrectomy is related to not only vagotomy,but also biliary bacterial infection. [更多还原