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PKC在脑损伤后血脑屏障损害中的作用

Effects of PKC on BBB in brain injury

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【作者】 李良平郭希高徐如祥蔡颖谦

【Author】 Li Liang ping , Guo Xigao, Xu Ruxiang Department of Neurosurgery,Zhujiang Hospital First Military Medical University,Guangzhou 510282

【机构】 第一军医大学珠江医院神经外科广东顺德市第一人民医院神经外科第一军医大学珠江医院神经外科 510282广州510282广州

【摘要】 目的:探讨PKC在脑损伤后血脑屏障损害中的作用。方法:雄性SD大鼠60只,随机分为正常对照组、假手术组、脑损伤组和H7治疗组。治疗组于伤后0.5h腹腔注射PKC阻断剂H7 1mg/kg,12h重复注射一次,荧光显微镜定性观察,分光光度计定量检测伊文氏兰渗出。结果:脑损伤后伊文氏兰明显渗出,治疗组渗出明显减少。结论:应用PKC阻断剂H7能明显阻止血脑屏障开放,表明PKC在脑损伤后血脑屏障损害中起重要作用。

【Abstract】 Objective: Aim To explore the effects of PKC on BBB damage in brain in jury. Methods: 60 male SD rats were devided into 4 of groups included control, Sham-operation, injury only and injury . with H7-treatment. The rats in the treatment group were peritoneally administered H7 (2mg/kg) at 0. 5h and 12h after brain injury. The permeation of Evans blue was observed qualitatively with an epifluorescence and quantitatively with a spectrophotometer. Resul ts: Evans blue significantly in the injured group while significantly decreases in treatment group. Conclusion: H7, a PKC blocker can prevent BBB opening significantly, these results indicate that the PKC take a important role on BBB damage in brain injury.

【关键词】 脑损伤血脑屏障蛋白激酶C
【Key words】 brain injury BBB PKC
  • 【文献出处】 脑与神经疾病杂志 ,Journal of Brain and Nervous Diseases , 编辑部邮箱 ,2000年05期
  • 【分类号】R743.3
  • 【被引频次】2
  • 【下载频次】85
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