【摘要】 目的 确定潍坊地区HLA-A、B多态性。方法 采用国际标准微量淋巴细胞毒试验对潍坊地区105名汉族青壮年进行HLA-A、B分型。结果 HLA-A位点以A2基因频率最高,为0.2895,其次为A9,频率较高者排列顺序为A2>A9>A19>A10>A11。B位点以D13基因频率最高,为0.1719,频率较高者排列顺序为B13>B5=B18>B40>B46。具有显著连锁不平衡的单倍型共有14种。结论 确定了潍坊地区HLA多态性特点,为开展骨髓移植、成分输血提供供体,为亲子鉴定及疾病相关分析提供依据。更多还原

【Abstract】 Objective To determine the HLA-A、B polymorphism character in the population of Weifang district. Methods By international standard micro-lymphocyte-eytotoxicity tests, we identified alleles at HLA-A、B loci of 105 adults in Weifang district, all of them are Hans. Results The most frequent allele in HLA-A loci is A2 gene, which is 0.289 5,then comes A9.The relative higher frequent genes in HLA A loci are A2>A9>A19>A10>A11 in order of fre quency. Whereas B13 gene of frequency 0. 171 9 ranks first in HLA-B loci,the relative higher are B13>B5 = B18>B40> B46 in order of frequency. There are 14 haplotypes altogether that present significant linkage disequilibrium. Conclusion We defined the feature of HLA polymorphism m Weifang population, which convenient the bone marrow transplantation、constituent blood transfusion in offering and analysis of correlation between HLA polymorphism and diseases in offering normal values.更多还原