【摘要】 探讨体外循环中大剂量国产抑肽酶的止血作用及机制。方法：１２０例体外循环心内直视手术病人随机分为抑肽酶组和对照组。实验组抑肽酶剂量６万ＫＩＵ／ｋｇ。选点测定血中ＰＣ、Ｆｉｂ、ＦＤＰ等指标的变化并观察术中术后的出血量和输血量。结果：用药组出血量和输血量分别比对照减少５０％左右。ＦＤＰ较对照组降低（Ｐ＜０．０５）。Ｆｉｂ较对照组增高（Ｐ＜０．０５）。结论：大剂量国产抑肽酶有明显的止血效果，抑制纤溶是止血的机制之一。更多还原

【Abstract】 To observe the reduction of postoperative bleeding after cardiopulmonary bypass(CPB) by high - dose aprotinin or placebo(control coup). Concentration of fibrin degradation products (FDP), fibrin(Fib) and platelet(PC) was analized as well as the amount of postoperative bleeding and transfu- sion. Results: the aprotinin group showed a significent reduction of postpetative bleeding and transfusion, lower con- cetration of FDP and higher of Fib. PC was not statitically different. Conclusion: high - dose aprotinin significently reduce postoperative bleeding in a possible way of fibrolysis inhibiion.更多还原