【摘要】 目的:通过18例肺癌肉瘤诊治,提高对罕见疾病肺癌肉瘤诊断、治疗及预后的认识.方法:回顾性分析18例肺癌肉瘤的临床表现、病理类型、X线特征及3例患者抑癌基因P53和P16的表达,并对其诊断、治疗及随访情况进行分析.结果:肺癌肉瘤临床特征及X线表现与原发性肺癌相似,但淋巴道转移较少,其p53和p16基因表达均未见异常突变.平均随访7年,其1年存活率为72.2%(13/18),3年生存率为61.2%(11/18),5年生存率为46.7%(7/15).结论:肺癌肉瘤预后与非小细胞肺癌相似,手术仍是首选治疗方式.更多还原

【Abstract】 Objective: To improve the understanding of the diagnosis, treatment and prognosis of rare disease - lung carcinosar-coma through analyzing 18 cases with such disease. Methods :Records of consecutive 18 patients treated from 1988~1998 were retro-spectively reviewed, P53 and P16 gene expression by immunohistochemistry in 3 of them were detected . Median follow ?up for sur-vivors was 7 years. Results: The clinical and radiograph characteristics of lung carcinosarcoma were similar to non - small cell lung cancer. But few of them spread through the lymph. Overall 1 - year, 3 - year and 5 - year survivals were 72.2% , 61.1 % and 46.7% respectirely. Conclusion: The prognosis of lung carcinosarcoma is similar to the non - small cell lung cancer,and surgery is the first choice treatment.更多还原