【摘要】 目的　探讨大剂量甲基强的松龙 (MP)对局灶性缺血再灌注大鼠脑保护作用的机理。方法　采用大鼠局灶性脑缺血再灌注模型 ,观察缺血前后应用大剂量 MP对大鼠大脑中动脉闭塞侧梗死体积的影响以及脑含水量的变化 ,同时观察脑组织病理学改变。结果　缺血前后 MP治疗组大脑中动脉供血区脑梗死体积较盐水对照组明显减小 (均 P<0 .0 1) ;缺血前后 MP治疗组与盐水对照组脑含水量比较无明显差别 (均 P>0 .0 5 )。病理学发现盐水对照组脑组织血管周围可见巨噬细胞浸润 ,而 MP治疗组无此病理改变。结论　大剂量 MP可改善缺血性脑损伤 ,其机理与减小缺血区梗死体积、抑制脑组织巨噬细胞浸润有关更多还原

【Abstract】 Objective To discuss the mechanism of large dose methylprednisolone(MP) on cerebral protection of rats after focal ischemic reperfusion.Methods Using the Wistar rat models of focal cerebral ischemic reperfusion,we observed the effects of large dose MP before and after ischemia on the volume of middle cerebral after infarction and the change of cerebral water content,meanwhile the pathological change of brain tissue was observed.Results Compared with the control group, the volume of middle cerebral after infarction in MD treatment group was remarkably reduced before and after ischemia (P< 0 01 );there was no difference on cerebral water content between the MP treatment group and the control group (P> 0 05 ). From the control group but not the MP treatment group, we found cerebral infiltration of macrophages from the histopathology of rat brain tissues.Conclusion Large dose MP might improve ischemic brain injury,the mechanism related to reducing volume of cerebral infarction and inhibited the infiltration of macrophages in the rat brain tissues.更多还原