【摘要】 目的　探讨血清转化生长因子 - β1 (TGF- β1 )在急性脑梗死 (ACI)发病过程中的变化及其意义。方法　采用酶联免疫吸附试验动态检测 35例 ACI患者血清 TGF- β1 浓度 ,分析其与梗死部位、大小、病情的相关性。结果　 ACI患者血清 TGF- β1 浓度急性期降低 ,恢复期升高。皮质梗死组 TGF- β1 高于皮质下组 (P<0 .0 5 ) ;梗死体积大则 TGF- β1 浓度高 (P<0 .0 5 ) ;重型组 TGF- β1 浓度高于轻型组 ,但无统计学意义。梗死组中白细胞和单核细胞数高于对照组 (P<0 .0 5 )。结论　血清 TGF- β1 的产生与外周血白细胞总数有关 ,其浓度的改变与梗死部位、大小及病程有一定关系 ,提示 TGF- β1 是一种负性免疫调节剂。更多还原

【Abstract】 Objective To evaluate the clinical significance and the change in pathogenic course of sera transforming growth factor β 1 (TGF β 1 ) in the patients with acute cerebral infarction(ACI).Methods Sera TGF β 1 concentrations of 35 patients with ACI were serially detected by ELISA,and analysed the relativity among TGF β 1 concentrations and focus size and severity of infarction.Results Sera TGF β 1 concentrations of the patients with ACI dropped in the acute phase and rose in the rehabilitation. TGF β 1 in cortex infarction group was higher than that of subcortex group( P <0.05);the larger the infarction size was,the higher the TGF β 1 was( P <0.05);TGF β 1 in severe group was higher than that in mild group,but no statistical significance. The number of WBC and mononuclear cells in ACI group was higher than that of control group( P <0.05).Conclusion The source of sera TGF β 1 related to the total of peripheral leukocytes, the change of sera TGF β 1 could correlate with the disease course and focus and size,it suggested TGF β 1 was a negative immunomodulator.更多还原