【摘要】 目的　探讨不同病因的脑白质疏松症 (L A)患者的 P30 0 特征。方法　选择 15 0例经 CT或 MRI诊断的 L A患者 ,并以 40名正常健康老年人作对照。以“听觉靶 -非靶刺激序列”为诱发事件 ,完成 P30 0 检测。结果　 L A患者中 ,37例无症状老年者较对照组靶和非靶刺激潜伏期 N1 、P2 、N2 和 P3延长 ,P3波幅降低 6 .3% ,但均无显著性差异 (P>0 .0 5 ) ;39例伴有脑血管病危险因素者较对照组 N1 、P2 虽延长 ,但均无显著性差异 (P>0 .0 5 ) ,N2 、P3均明显延长 ,P3波幅降低 31.3% ,均有显著性差异 (P<0 .0 5 ) ;38例伴有脑血管病者和 36例伴有血管性痴呆者较对照组 N1 、P2 、N2 和 P3均明显延长 ,P3波幅分别降低 48.4%和 6 0 .9% ,均有非常显著性差异 (P<0 .0 1)。结论　 P30 0 能够对不同病因的 L A患者认知功能作出全面客观的评价。更多还原

【Abstract】 Objective To investigate the feature of auditory P 300 in different patients with leukoaraiosis (LA). Methods An “oddball” paradigm was used to elicit the auditory P 300 from 150 patients with LA by CT or MRI,and as compared with 40 normal health old persons.Results In the patients with LA,N 1, P 2, N 2 and P 3 of 37 asymptomatic old persons lengthened and their P 3 amplitude decreased 6.3% as compared with the controls;but there was no significant difference (P>0.05).39 patients with risk factors of cerebrovascular di seases showed the lengthening of N 1, P 2 latencies, but there was no significant difference (P>0.05),N 2, P 3 latencies lengthened remarkable,and their P 3 amplitude decreased 31.3% (P<0.05). 38 patients with cerebrovascular diseases and 36 patients with vascular dementia showed the lengthening of N 1, P 2, N 2 and P 3 as compared with the control group, P 3 amplitude decreased 48.4% and 60 9%,there was remarkable difference(P<0.01).Conclusion The auditory P 300 could evaluate the cognitive functions of different patients with LA.更多还原