【摘要】 目的 :探讨精神分裂症患者 P3异常的意义 ,以及抗精神病药物可能的影响。　方法 :对2 1例精神分裂症患者在发病期及 2年缓解期后采用视觉图像辨认作业引出 Cz点 P30 0 进行研究。　结果 :病例组发病期与缓解期均有 P3潜伏期延长与波幅下降 ,较正常对照有统计学意义。　结论 :P3可作为一种潜在的认知功能评价工具 ,应用于精神病学研究。更多还原

【Abstract】 Objective:To explore the meanings of P 3 abnormality in schizophrenia and determine whether this abnormality could be attributed to the effects of maintenance of antipsychotic medications. Method:The P 300 event related potentials(ERPs) of Cz during a visual discriminative task were recorded in 21 schizophrenic (DSM Ⅲ R) patients in both their episode and after clinical remission for two years. The P 300 were also made in 24 age and education matched normal control subjects. Results:Mean latencies and amplitudes of the P 3 in schizophrenic patients in both episode and remission significantly differed from those of normals; and the P 3 abnormalities were simillar between maintenance and non maintenance groups. Conclusion:It is suggested that the P 3 amplitude reduction and latency prolongation,which indicate an impairment of visual cognitive information processing in this study,are partly independent of clinical state in schizophrenia,and maintenance of medication has little influence on these abnormalities.更多还原