【摘要】 目的　探讨癌基因蛋白表达在骨巨细胞瘤生物学行为与预后方面的意义。方法　对 46例骨巨细胞瘤 (含 10例肿瘤复发 )进行Jaffe分级与综合分级 ;同时镜下确认有否侵袭周围组织与出血坏死 ,结合免疫组织化学技术检测Ki6 7,bcl 2 ,c erbB 2及nm2 3 4种癌基因蛋白表达。结果　在肿瘤的出血坏死、侵袭与复发方面 ,Ⅰ、Ⅱ、Ⅲ级之间的差异无显著性 ,Ⅲ级分类与综合分级也无相关性。 4种癌基因产物的表达在一定程度上与其侵袭复发有关。结论　单纯Ⅲ级分类法在反映骨巨细胞瘤的生物学行为方面存在着一定的局限性。癌基因产物的表达参照综合分级可能成为推断骨巨细胞瘤的性质与预后重要参考指标。更多还原

【Abstract】 Objective To study the correlation of expression of oncogene proteins with the invasion and recurrence of giant cell tumor (GCT) of bone and its various cytologic grades. Methods According to Jaffe classification and comprehensive grades, 46 cases (10 of which recurred after operations) were classified, with its invasion, hemorrhage and necrosis degrees being evaluated by microscope. In addition, the expression of oncogene proteins including Ki67, bcl 2, c erbB 2 and nm23 were detected by S P immunohistochemistry. Results The three degrees of Jaffe classification were unable to accord rightly with biological behaviors of GCT as well as comprehensive grades, while the expression rates of oncogene products corresponded with the tumor invasion and recurrences to a certain degree. Conclusion Detection to oncogene products, in combination with comprehensive grades, may become a helpful method to settle the exact nature and prognosis of GCT.更多还原