【摘要】 探讨病毒性肝炎VH时机体的神经内分泌变化。以放免法检测 2 97例各型VH及肝硬化 (LC)患者血浆血管紧张素Ⅱ (ATⅡ )、皮质醇 (CT)、血栓烷B2 (TXB2 )、6 -酮 -前列腺素F1α( 6 -Keto -PGF1α)含量 ,并同步检测肝功能。ATⅡ、CT在急性期均增高。LC组血浆ATⅡ水平呈最高值 ,CT值与对照组无异。TXB2 在重肝组降低。ATⅡ、CT在疾病恢复期下降 ,ATⅡ在加重期增高。ATⅡ、CT、TXB2 与多项肝功相关。VH患者有明显的神经内分泌失调。ATⅡ是与肝病密切相关的激素之一。更多还原

【Abstract】 A study on some neuroendocrine changes for viral hepatitis (VH) was undertaken.The serous levels of angiotensn Ⅱ (ATⅡ),cortisol (CT), thromboxane B 2 (TXB 2) and 6 ketoperstaglandin F1 α (6 keto PGF1 α) were measured by radioimmunoassay in 297 cases of different types of VH and liver cirrhosis (LC),in the same time liver functions were detected as well.The levels of both AT Ⅱ and CT obviously elevated in patients in acute period,and AT Ⅱ elevated to the highest level in LC group,while no changes were found for level of CT.The level of TXB 2 obviously decreased in fulminant hepatitis (FH) group.Both levels of AT Ⅱ and CT obviously decreased in restored period but the level of AT Ⅱ elevated in the severe period of disease.A correlation between the several indices of liver functions and AT Ⅱ,CT as well as TXB 2 was found,especially a positive orrelation both the AT Ⅱ and total bilirubin (TBIL),where as a negative correlation between the AT Ⅱ and albumin (ALB) as well as cholinesterase (CHE) was found.A neuroendocrine imbalance participated in the course of VH.AT Ⅱ is a hormone close correlating clinical manifestation of hepatic diseases.更多还原