【摘要】 目的　探讨肺癌组织的MRI相对信号强度与增殖细胞核抗原 (PCNA)之间的关系。材料与方法　 2 6例肺癌患者 ,术前用Resonex 0 .3 8T磁共振成像系统 ,行横断面SET1WI ,GR序列成像 ,增强后行SET1WI。术后标本采用ABC免疫组化技术 ,观察PCNA在 2 6例肺癌中的表达。结果　Gd DTPA增强后增殖活性较低的肿瘤细胞 ( 5 % <PCNA≤ 5 0 % ) ,其MRI相对信号强度增加值明显大于增殖活性较高的肿瘤细胞 (PCNA >5 0 % )的增加值 (P <0 .0 5 )。肺癌病灶的MRI形态学特征与PCNA间无相关性。结论　肿瘤细胞吸收Gd DTPA的多少与其增殖活性的高低有关 ,因此MRI信号强度在一定程度上可反映肿瘤细胞的增殖情况 ,从而间接地反映肿瘤细胞的生物学行为更多还原

【Abstract】 Objective To investigate the relationship of MRI relative signal intensity and the expression of PCNA in lung carcinoma.Materials and Methods SE T 1WI, gradient echo and Gd DTPA enhanced SE T 1WI scanning were performed in 26 cases of pathologically proved lung cancer with a 0.38T MR unit. The expression of PCNA was measured by using ABC immunohistochemical methods.Results The expression of PCNA was significantly related to the increase of MRI relative signal intensity (SI rel ) (P<0.05). MRI morphological characters of lung cancer bore no relationship to PCNA.Conclusion The increase of MRI relative signal intensity (SI rel ) provides a useful quantitative indicator to predict the cell proliferation (PCNA) with a certain degree, and, therefore, indirectly reflects the degree of malignancy of the biological behavior of lung cancer.更多还原