【摘要】 目的 :探讨变应性鼻炎与气道高反应性的相关性。方法 :用 1∶ 1 0 0 ( w/v)蒿属花粉对 50例变应性鼻炎和 2 0例正常者做支气管激发试验 ,分别测定两组第 1秒用力呼气量 ( FEV1) ;测血清中嗜酸性粒细胞阳离子蛋白 ( ECP)。结果 :支气管激发试验前 ,两组支气管均无症状 ,鼻炎组FEV1为 ( 70± 2 0 ) % ,对照组为 ( 85.6± 8.9) % ,两组有显著性差异 ( P <0 .0 1 ) ;支气管激发后 ,鼻炎组中 2 3例胸部有紧迫感 ,1 0例有哮鸣 ,5例有喘息 ,1 2例无症状 ,激发阳性率为 76%。对照组均无支气管症状。激发后鼻炎组 FEV1为 ( 60± 2 0 ) % ,对照组为 ( 85.6± 8.9) % ,两组有显著性差异 ( P <0 .0 5)。鼻炎组 ECP为 ( 30 .37± 1 8.92 ) μg/L,对照组为 ( 5.2 4± 3.2 3) μg/L,两组有显著性差异 ( P <0 .0 5)。结论 :变应性鼻炎不仅鼻粘膜有变态反应所致的慢性炎症 ,而且大部分气道也有慢性炎症反应而导致气道高反应性。更多还原

【Abstract】 Objective:In order to study the relationship between allergic rhinitis and airway hyperresponsiveness.Method:Each of them were separately engaged skin test with antigen.All 50 patients had intense positive reaction to artemisia pollen (～),but all controls were negative.We conducted bronchial provocation test (BPT) with 1∶100 (w/v) artemisia pollen.Before and after BPT,we separately tested the forced expiratory volume in first second (FEV 1) which represented ventilative function and eosinophil cationic protein (ECP) in their serum.Result:Before BPT,50 patients and 20 normal controls had no trachea symptoms.FEV 1 of 50 patients is (70±20)%,that of normal controls is ( 85.6 ± 8.9 )% (P< 0.001 ).After BPT,in 50 patients,23 cases felt constriction in the chest,10 cases had wheezes,5 cases had asthma,12 cases had no symptoms.At the same time,all of normal controls had no symptoms.After BPT,FEV 1 of 50 patients is (60±20)%,that of normal controls was ( 85.6 ± 8.9 )%(P< 0.05 ),ECP of patients was ( 30.37 ± 18.92 )μg/L,that of controls was ( 5.245 ± 3.228 )μg/L (P< 0.05 ).Conclusion:Patients with allergic rhinitis not only have chronic inflammation in their nose mucosea that results from allergic react,but also have chronic inflammation in bronchus which leads to AHR.The results reveal that most patients with allergic rhinitis have AHR (76%).更多还原