【摘要】 为分析小儿急性淋巴细胞白血病诱导化疗早期骨髓象与预后的关系,对108例初治小儿急性淋巴细胞白血病进行MIC分型并随访,于诱导化疗第8天行骨髓检查,以骨髓幼稚细胞≤0.20为A组,骨髓幼稚细胞>0.20为B组。结果:(1)A组生存率明显高于B组(分别为84.2％和18％,P<0.05)。(2)A组中临床高危型比例明显低于B组(分别为27％和66％,P<0.05)。(3)临床普危型的病例中A组复发率明显低于B组(分别为3.9％和46％,P<0.05)。对临床难以分型的小儿急性淋巴细胞白血病,诱导化疗第8天骨髓检查对高危型判断有重要价值。更多还原

【Abstract】 In order to explore the prognostic evaluation of early bone marrow examination during induction chemotherapy in children with acute lymphoblastic leukemia (ALL), bone marrow puncture was performed on day 8 during the first course of the induction chemotherapy in 108 children with ALL who were divided in to group A and group B based on juvenile leucocytes≤0. 2 or>0. 2 in their myelogram. The results showed that the survival rate in the A group was significantly higher than that in the B group (84. 2% vs. 18%, P<0. 05). The proportion of high-risk patients in A group was obviously lower than that in B group (27% vs. 66% , P<0. 05). The recurrence rate in the A group also decrease remarkably than that in the B group (3. 9% vs. 46% , P<0. 05). It is concluded that early bone marrow examination during induction chemotherapy is valuable for the evaluation of high risk in the children with ALL.更多还原