【摘要】 本文应用全国脑防办双盲编号的国产降纤酶静滴治疗发病24h以内的急性脑梗塞病人34例．降纤酶治疗组21例，对照组13例．在应用降纤酶治疗前进行神经功能缺损评分．在出院时和第12周进行两次病人日常生活功能的评估（Barthel氏指数）．并同时于治疗前、后检测血浆中纤维蛋白原含量、肝功、肾功．研究结果显示，近期疗效降纤酶治疗组优于对照组，神经功能缺损评分进步亦优于对照组，但不具备统计学显著性差异（P＞005）．病人第12周日常生活能力评估（Barthel氏指数）较出院时有显著进步（P＜0．001）。研究显示国产降纤酶确为有效降低血浆纤维蛋白原的药物，对急性脑梗塞治疗有一定的疗效．更多还原

【Abstract】 Thirty-four patients with acute cerebral infarction for 24 hours were treated by injection of defibrase numbered using double blind by the National Brain Disease Treatrnent and Preventive Office, with 21 patients treated with defibrase and 13 patients as the control. The nerve function deficit score was evaluated before treatment, and the routine life ability (Barthel index) was evaluated at discharge, and week 12. The serurn fibrinogen concentraion, hepatic function. and nephritic function were tested before and after treatment with defibrase. The results showed that the effect of early period and nerve function deficit score with defibrase were superior to those of the control group, no significant difference (P>0.05). The routine life ability at week 12 improved apparently than that at discharge (P<0.001).The fibrinogen concentration was decreased significantly than that of the control group (P<0.001).The results suggest that the homemade defibrase is an effective drug in decreasing the fibrinogen concentraion and treating acute cerebral infarction.更多还原