【摘要】 目的:针对TMD的临床症状,研制氯唑沙宗乳膏透皮制剂、缓解痉挛,消除疼痛.方法:以体外透皮试验考察药物对皮肤的通透情况,通过动物实验研究本乳膏对士的宁致小鼠惊厥的抑制作用和经家兔皮肤吸收的药物代谢动力学,以高效液相色谱法测定血药浓度.选择合适患者进行临床观察.结果:本乳膏疗效持续时间长,血药浓度变化平稳.药物经皮吸收与口服在抗小鼠惊厥方面无明显差异.临床评价试验组总有效率为86.36%,对照组为72.72%.结论:本乳膏具有与口服用药同样的治疗效果,且作用持久,无肝脏及胃肠道损害.更多还原

【Abstract】 ve: Aimed at the major symptoms of temporomandibular disorders(TMD). To study transdermal pharmaceutics of chlorzoxazone cream for reducing spasm and pain of TMD patients. Methods: Investigate penetration of the drug by in vitro transdermal test. Study inhibition effect of chlorzoxazone cream to mouse convulsion resulted from strychnine and pharmacokinetics of transdermal absorption of the pharmaceutics through the skin of rabbits. Measure blood concentration of the drug by HPLC. Results:The effect of the transdermal pharmaceutics lasts much longer than peroral administration and the blood concentration of the drug of transdermal delivery changes smoothly comparing with peroral. There is no significant difference in inhibition between transdermal therapy and peroral therapy groups. The total effective rate of the test group is 86.3%, whereas that of the control group is 72.72%. Conclusion: Without hepar’s first pass effect, chlorzoxazone cream has the same effect as peroral administration and the blood concentration keeps longer than peroral.更多还原