【摘要】 分析多糖和姜黄素对脂蛋白 (a)和去唾液酸脂蛋白 (a)代谢的影响 ,从刺猬腋下静脉注入甘露聚糖、壳聚糖、α -酸性糖蛋白和姜黄素 ,2min后注射12 5I-脂蛋白 (a)或12 5I-去唾液酸脂蛋白 (a) ,1h后处死动物 ,测定血、肝、肾、脾、胆汁和肾上腺的同位素含量。结果发现 ,脂蛋白 (a)去唾液酸后能大量进入肝脏 ,加速在体内的分解代谢 ,使血中浓度迅速降低。α -酸性糖蛋白抑制组织对脂蛋白 (a)和去唾液酸脂蛋白 (a)的摄入 ,使血中脂蛋白 (a)和去唾液酸脂蛋白 (a)含量显著增高。壳聚糖和姜黄素增加肝脏和肾上腺对脂蛋白 (a)的摄取 ,使血中脂蛋白 (a)含量略降低 ,但对去唾液酸脂蛋白 (a)代谢无明显影响。甘露聚糖增加脾脏对脂蛋白 (a)的摄取 ,减少胆囊中脂蛋白 (a)含量 ,但增加肾脏和胆囊对去唾液酸脂蛋白 (a)的摄取 ,降低肾上腺对去唾液酸脂蛋白 (a)的摄取。结果提示 ,脂蛋白 (a)去唾液酸后能使脂蛋白 (a)分解代谢加快 ,脂蛋白 (a)分子中的唾液酸在结构稳定中起重要的作用。α -酸性糖蛋白抑制脂蛋白 (a)和去唾液酸脂蛋白 (a)代谢 ,而壳聚糖和姜黄素则促进脂蛋白 (a)代谢更多还原

【Abstract】 Aim To study the effects of mannan, chitin, orosomucoid and cucurmin on the metabolism of lipoprotein (a) and desialylated lipoprotein(a). Methods Mannan, chitin, orosomucoid and cucurmin was injected into the body of hedgehogs via the armpit vein 2 min before the 125 I-Lp(a) or 125 I-dsLp(a). The animals was put to death in an hour. The radioactivity 125 I-Lp(a) and 125 I-dsLp(a) in the blood, liver, kidney, spleen, gall and adrenal were measured. Results The absorption of dsLp(a) in the liver is larger than that of Lp(a). It makes the concentration of dsLp(a) decrease in blood. Orosomucoid is a strong inhibitor of catabolism of Lp(a) and dsLp(a). It can inhibit the absorption of Lp(a) and dsLp(a) by the mentioned tissue and makes the concentration of Lp(a) and dsLp(a) in the blood increase. The effects of chitin and cucurmin are similar. They can increase the absorption of Lp(a) by liver and adrenal and make the concentration of Lp(a) decrease in blood. The effects of chitin and cucurmin can affect the metabolism of Lp(a), but not dsLp(a). The effects of mannan on the metabolism of Lp(a) and dsLp(a) are little. It can increase the absorption of Lp(a) by spleen and reduce the concentration of Lp(a) in the gall. Moreover, it can increase the absorption of dsLp(a) by kidney and gall, reduce the absorption of dsLp(a) by adrenal. Conclusions It is the key step of catabolism of Lp(a) that Lp(a) is desialylated. Sailic acid in Lp(a) molecular play an important role in its stability of structure. The experiments show that orosomucoid can inhibit the metabolism of Lp(a) and dsLp(a), chitin and cucurmin can promote the matabolism of Lp(a).更多还原