【摘要】 目的 了解社区老年期痴呆的发病率及相关因素。方法 以1992年上海县8个乡(镇)老年期痴呆患病率调查时的1515例样本对象(按整群分层随机抽样方法抽出的实访样本数),4.5年后进行老年性痴呆的发病率调查,并对初筛中MMSE分值较低者226人作载脂蛋白E(apoE)基因分型。结果 在55岁以上老年人群中,痴呆的年发病率为0.53％,其中AD的年发病率为0.34％,VD(血管性痴呆)为0.15％,其它痴呆为0.04％,并显示AD的发病率和年龄、教育程度及apoE4基因之间存在密切关系。结论 社区老年人群中的AD的发生率最高,与APOE等有关。更多还原

【Abstract】 Objective: To investigate the incidence of senile dementia in community. Method: On the basis of the previous prevalence study of senile dementia conducted in 1992. the incidence of senile dementia in this sample was investigated and the genotypes of the APOE gene were determined 4. 5 years later. Results: The yearly incidence of senile dementia was 0. 53% in the population aged over 55. The incidence of Alzheimer’s disease (AD) , vascular dementia and other types of dementia was 0. 34% , 0. 15% and 0. 04%, respectively. AD was closely related to the patient’s age, education level and APOE gene. Conclusion: The results suggested that AD was the major form of senile dementia in the elderly population and that APOE 4 gene could be one risk factor.更多还原