【摘要】 目的 :探讨遗传因素与食管癌的关系。方法 :通过遗传流行病学病例对照研究方法 ,对海安县 2 6 5个食管癌先证者家系和 2 6 5个对照家系进行分离比、遗传度估计。结果 :食管癌先证者一级亲属的发病率 (5 .38% )明显高于对照一级亲属的发病率 (2 .81% ) ,食管癌遗传度为 2 4.2 4% ,分离比为 0 .12 14,小于 0 .2 5 ,属多基因遗传疾病。结论 :海安县食管癌的病因中 ,遗传因素起重要作用更多还原

【Abstract】 Objective:To explore the relationship between Genetic factor and Esophageal Cancer in Haian.Method:A genetic Epidemiologic case control study including 256 pridegrees(256 cases and 256 controls)were carried out to estimate the heritabi lity and the segredation ratio in Haian.Result:The results showed that incidence rate of the first degree relatives in cases was 5.38%,significantly higher than that in control cases(2.81%).The heritability of esophageal cancer was 24.24%,Segregation rentio was 0.1214 which was lower 0.25.It means that the geneticmodel factor belonged to polygenetics.Conclusion:It suggested that the hereditary factor was important in occurance of esophageal cancer in Haian county.更多还原