【摘要】 目的 :主要研究纤连蛋白抗体和层粘连蛋白抗体对胚泡着床的影响。方法 :取孕 4天小鼠 ,分别在两侧子宫角内注射纤连蛋白及层粘连蛋白抗血清 ,于孕 8天检查胚胎着床数 ,取子宫观察内膜的组织学及免疫组织化学变化。结果 :纤连蛋白抗血清及层粘连蛋白抗血清均有显著抑制胚泡着床的效应 ,组织学及免疫组化结果表明 ,纤连蛋白抗血清及层粘连蛋白抗血清可引起蜕膜细胞退化解体 ,拮抗纤连蛋白及层粘连蛋白在蜕膜组织中的表达。结论 :纤连蛋白 ,层粘连蛋白对胚泡粘附着床起重要作用更多还原

【Abstract】 To evaluate the effects of specific fibronectin(FN) antiserum and laminin(LN) antiserum on mice blastocyst implantation. Methods: Pregnant mice were given FN antiserum and LN antiserum by intra uterus injection. The numbers of embryo implantation were examined and the histological and immunohistochemical variances in endometrium were observed. Results: Both FN antiserum and LN antiserum produced significant effects on repressing mouse blastocyst implantation. Conclusion: FN and LN in mice may play an important role in the process of blastocyst attachment and implantation.更多还原