【摘要】 目的 研究双微体（ｄｏｕｂｌｅ ｍｉｎｕｔｅｓ，ＤＭ）在膀胱移行上皮细胞癌中的表达及其意义。方法 正常对照组 １５例，膀胱移行上皮细胞癌术前术后组各１４例，采用外周静脉血全血培养，常规染色体准备，检测ＤＭ的表达，采用统计学ｘ２检验。对ＤＭ的表达与临床病理因素及预后的关系进行分析。结果 正常对照组无ＤＭ检出，术前术后组分别有３５和 ３１对ＤＭ检出，与对照有显著性差别（Ｐ＜０．０１），且集中于两例ＤＭ阳性病例，但术前术后无显著性差别（Ｐ＜０．０５）。结论ＤＭ可作为癌基因扩增的一项独立的预后指标，ＤＭ阳性患者，预后差，易复发。更多还原

【Abstract】 Objective To investigate the expression of double minutes (DM) in bladder transitional cell carcinoma (TCC) and its significance. Methods 15 control individuals and 14 patients were examined. Whole blood samples from these patients were cultured before and 10-15 days after operations. The relationship between expression of DM and clinic-pathologic factors and prognosis was ana- lyzed by chi-square test. Results There is no DM in control individuals, but there are respectively 35 pairs and 31 pairs DM in preop- erative and optoperative patients with TCC (P < 0. 01 ) and concentrate in two DM (+ ) patients. However, the difference between preoperative and postoperative patients was not statistically significant(P > 0. 05). Conclusions DM may be an independent prognosis indication of cancer gene amplication. DM always show treatment failure and rapid recurrence.更多还原