【摘要】 具有钙拮抗作用的中药制剂丹皮酚在非细胞毒性剂量下能降低化疗药物阿霉素 (ADM)、柔红霉素 (DAU )、长春新碱 (VCR)及长春花碱 (VL B)对多耐药 (m ulti drug resistance,MDR)肿瘤细胞株 K5 6 2 /ADM细胞的 IC5 0 ,且能提高细胞内化疗药物的浓度 ,但对细胞膜 P-糖蛋白的表达没有影响 ,表明丹皮酚具有逆转人红白血病细胞株 K5 6 2 /ADM细胞 MDR作用更多还原

【Abstract】 The calcium channel blocker paeonol (a herb medicine) could reduce the value of IC 50 of Adrimycine (ADM), Daunorubicin (DAU), Vinblastin (VLB), and Vincisrine (VCR) against MDR cell line K 562 /ADM, and enhanced accumulation of ADM, DAU, VCR and VLB within cells at non cytotoxic dose, but did not cause the change of the Pgp expression. The results indicate that paeonol could reverse the MDR in human erythroleukemin cell line K 562 /ADM更多还原