【摘要】 采用大鼠脑室内微量反复注射喹啉酸（quinolinicacid，QA）造成的学习记忆障碍模型和自然衰老大鼠，测定其学习记忆功能和脑内胆碱能神经系统的变化。结果显示，QA模型的学习记忆能力明显受损，脑内胆碱能神经标志酶ChAT活性明显下降。脑海马、大脑皮层胆碱能毒蕈碱受体（MR）结合活性分别降低30％和26％；烟碱受体（NR）结合活性分别降低33％和27％，并较老年鼠明显。进一步发现，各组外周脾淋巴细胞膜胆碱能受体活性的改变与脑内变化一致。提示外周生物学指标可能间接反映中枢神经功能的变化而成为诊断某些脑疾患的重要参考。更多还原

【Abstract】 We used the learning and memory impairment model established through intraventricular injection of QArepeatedly, to observe the functional changes of central cholinergic nerve and their reflects on the peripheral lymphaticsystem . There were a significant decline of cholineacetyltransferase (ChAT) in cerebral cortex and hippocampus afterQA injection. We also found the lower binding activities of M-and N-cholinergic receptors in hippocampus and cortexin QA group significantly than in the PBS group (P<0.01). Furthermore, the binding activities of M-and N-receptorsof spleen lymphocytes as well as those in brain were improved in each group. The results suggest that certain lesionof the centhel nerve system function can be reflected through peripheral biochemical parameter, which is an importantreference to diagnose the changes of the central nervous system.更多还原