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Effects of garlic oil on tumoragenecity and intercellular communication in human gastric cancer cell line

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【作者】 李晓光谢锦玉李文梅季加孚崔建涛赵敏孙梅吕有勇

【Author】 LI Xiaoguang XIE Jinyu LI WenmeiJl Jiafu CUI Jiantao ZHAO MinSUN Mei & LU YouyongChina Rehabilitation Research Center, Beijing 100077, China;China Academy of Traditional Chinese Medicine, Beijing 100700, China;Beijing Institute for Cancer Research, The School of Oncology, Beijing Medical University, Beijing 100034, China

【机构】 China Rehabilitation Research CenterBeijing 100077ChinaChina Academy of Traditional Chinese MedicineBeijing 100700ChinaBeijing Institute for Cancer ResearchThe School of OncologyBeijing Medical UniversityBeijing 100034China

【摘要】 <正> Previous studies have demonstrated that garlic oil (GO) and its anti-tumor compound could inhibit DNA and RNA synthesis in human cancer cells. In order to explore the effects of garlic oil on carcinoma cells, a gastric carcinoma cell line, BGC-823 was studied at cellular and molecular levels after garlic oil treatment. Data showed that the cell differentiation and suppression of tumorigenicity were significantly induced in tumor cells after garlic oil treatment. There was a correlation between the cell-cell communication recovery and the increase of p53 and waf1/p21 gene expression in garlic oil-treated cells. This result suggested that tumor suppressor gene waf1/p21 and wt p53 might play an important role in this effect.

【Abstract】 Previous studies have demonstrated that garlic oil (GO) and its anti-tumor compound could inhibit DNA and RNA synthesis in human cancer cells. In order to explore the effects of garlic oil on carcinoma cells, a gastric carcinoma cell line, BGC-823 was studied at cellular and molecular levels after garlic oil treatment. Data showed that the cell differentiation and suppression of tumorigenicity were significantly induced in tumor cells after garlic oil treatment. There was a correlation between the cell-cell communication recovery and the increase of p53 and waf1/p21 gene expression in garlic oil-treated cells. This result suggested that tumor suppressor gene waf1/p21 and wt p53 might play an important role in this effect.

  • 【文献出处】 Science in China(Series C:Life Sciences) ,中国科学(C辑:生命科学)(英文版) , 编辑部邮箱 ,2000年01期
  • 【分类号】R735.2
  • 【被引频次】3
  • 【下载频次】53
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