【摘要】 目的　研究原发性痛经的遗传易感性。方法　收集了某纺织厂 499名新婚女工的资料 ,采用 L ogistic回归分析对氧磷 1(PON1)和对氧磷 2 (PON 2 )两基因遗传多态性与原发性痛经的关系。结果　在未调整环境影响因素下 PON1Arg192 Gln/ Gln192 Gln基因型可明显增加痛经危险度 ,而 PON2 Ala148Ala基因型虽对痛经有增强趋势 ,但无统计学意义。 (PON1:OR=1.91,95 %CI 1.33～ 2 .75 ;PON2 :OR=1.33,95 % CI 0 .84～ 2 .11)。调整潜在影响因素后 ,PON1Arg192Gln/ Gln192 Gln基因型仍显示增加痛经危险度 ,而 PON2 Ala 148Ala基因型虽显示有增强痛经趋势 ,但仍无统计学意义。 (PON 1:OR=2 .0 1,95 % CI 1.36～ 2 .96 ;PON2 :OR=1.31,95 % CI0 .80～ 2 .13)。分析 PON1和 PON2基因间交互作用结果显示 ,同时存在 PON1Arg192 Gln/Gln192 Gln和 PON 2 Ala148Ala基因型时 ,可明显增加原发性痛经危险度 (OR=1.86 ,95 % CI1.0 7～ 3.2 3) ,但显示出的基本上仍然是 PON1的影响。结论　表明原发性痛经与 PON1基因遗传多态性相关。更多还原

【Abstract】 Objective To investigate genetic susceptibility of primary dysmennorrhea. Methods This study collected data of 499 female workers in textile mill. The association of PON1 and PON2 polymorphisms with primary dysmennorrhea were evaluated by logistic regression analysis with adjustment for potential confounders. Results PON1 Arg192 Gln/Gln192 Gln genotypes had significantly increased risk of dysmennorrhea, while PON2 Ala148 Ala genotype slightly increased risk of dysmennorrhea, but it was not statistically significant, (PON1: OR=1.91, 95% CI 1.33～2.75; PON2: OR=1.33, 95% CI 0 84～2.11). After adjusted potential confounders, PON1 Arg192 Gln/Gln192 Gln genotypes had significantly increased risk of dysmennorrhea yet, and PON2 genotypes showed increased risk of dysmennorrhea, but it was still not statistically significant(PON1: OR=2.01, 95% CI 1.36～2.96; PON2: OR=1.31, 95% CI 0.80～2.13). Analysis of interaction between PON1 and PON2, if PON1 Arg192 Gln and Gln192 Gln PON2 Ala148 Ala existed at the same time, they had significantly increased risk of dysmennorrhea(OR=1.86, 95% CI 1.07～3.23), but this was affected by PON1. Condusions Variation in PON1 is significantly associated with primary dysmennorrhea.更多还原