【摘要】 目的　比较妊高征 (PIH)孕妇外周血及其新生儿脐血SCE频率 ,以探讨PIH母婴DNA损伤情况并提高其监测水平。方法　采用紫外光照射 ,SCE分化染色法对 2 1例PIH病人和 15例正常孕妇 (对照组 )外周血及其所分娩新生儿脐血进行SCE测定。结果　PIH组外周血和脐血SCE频率分别为 6.11± 1.2 9,5.98± 1.38;对照组外周血和脐血SCE频率分别为 3.4 5± 0 .71,3.16± 0 .57。两组比较有极显著性差异 (P <0 .0 0 1)。结论　PIH孕妇及新生儿皆有遗传物质DNA的损伤 ,SCE频率可作为一项诊断、监测PIH的重要指标更多还原

【Abstract】 Objective To compare sister chromatid exchange(SCE)frequency in lymphocytes in infants and umbilical blood of pregnant women with pregnancy induced Hypertension (PIH),to probe into their DNA damage state and best assay about PIH.Methods The frequency of SCE in peripheral blood lymphocytes of 21 pregnant women with PIH and 15 normal pregnant women as well as the umbilical blood of their infants were investigated using ultraviolet ray and SCE dividing color.Results The mean frequency of SCE in infants and umbilical blood with normal pregnancy were 3.45 ±0.71 and 3.16 ±0.57 respectively,while they were 6.11±1.29 and 5.98±1.38 in PIH group respectively.There was statistically significant difference between two groups (P<0.001).Conclusion Pregnant women with PIH and their infants both exist hereditary material DNA injury.SCE may be a new diagnostic index to detect PIH.更多还原