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哮喘患儿血清IL-12、IL-6及IgE水平变化的研究

THE CHANGES OF IL-12,IL-6 AND IgE IN SERUM OF CHILDREN WITH ASTHMA

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【作者】 刘雅明江志雄李珊黄先玫

【Author】 LIU Ya-ming,LI Shan,HUANG Xian-mei.Paediatric Department of Hangzhou Medical College,Hangzhou(310012)

【机构】 杭州医学高等专科学校儿科学教研室!杭州310012解放军117医院儿科!杭州310013杭州医学高等专科学校附属医院儿科!杭州310015

【摘要】 目的 :研究哮喘患儿发作期与缓解期血清IL 1 2、IL 6与IgE水平。 方法 :选择符合哮喘诊断标准发作期患儿 2 5例 ,缓解期患儿 1 1例 ,取其静脉血检测血清IL 1 2、IL 6和IgE水平。 结果 :发作期IL 1 2水平明显降低 ,与缓解期比较差异有显著意义 (P <0 .0 5)。发作期IgE水平明显升高 ,与缓解期比较差异也有显著意义 (P<0 .0 5)。IL 6水平在发作期升高 ,缓解期下降 ,但两者比较差异无显著意义 (P >0 .0 5)。结论 :小儿哮喘是一种慢性气道炎症 ,在缓解期仍需抗炎治疗

【Abstract】 Objective:To investigate the levels of serum IL-12,IL-6 and IgE were measured by ELISA in 25 cases at stage of episode and 11 cases at stage of remission.Methods:The serum IL-6,IL-12 and IgE were measured by ELISA in 25 cases at stage of episode and 11 cases at stage of remission.Results:The level of serum IL-12 at stage of episode was significantly lower than that at stage of remission ( P<0.05 ).IgE level was higher at stage of episode than that at stage of remission( P<0.05 ).The IL-6 level was slightly higher in the episode stage,but the difference was not significant between the two groups( P>0.05 ).Conclusion:The chronic inflammation of the respiratory tracts is one of the main physiopathological mechanism of asthma.Anti-inflammatory treatments are necessary at stage of remission.

  • 【文献出处】 杭州医学高等专科学校学报 ,JOURNAL OF HANGZHOU MEDICAL COLLEGE , 编辑部邮箱 ,2000年03期
  • 【分类号】R562.25
  • 【被引频次】1
  • 【下载频次】33
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