【摘要】 采用体外细胞培养技术 ,研究了海洋硫酸多糖 911(以下简称 911)体外对 HIV- 1感染 MT4 、H9细胞的影响及其细胞毒性作用 ,结果表明 :911可明显抑制 HIV- 1对 MT4 细胞的急性感染和 H9细胞的慢性感染 ,其半数有效浓度 ( EC50 )分别为 4 .4 4 μg· m L-1和 0 .32 μg· m L-1;911体外对 MT4 细胞和 H9细胞的半数中毒浓度分别为 7.78mg· m L-1和 7.4 7mg·m L-1,治疗指数分别达 1752和 2 3714。提示 911为低毒的 HIV-1增殖抑制剂更多还原

【Abstract】 The effects of marine polysaccharide 911 on HIV1 proliferation and its cytoxicity as well were studied in this paper. The results indicated that 911 inhibited both acute and chronic infection of HIV1 to MT 4 and H 9 cells with its half effect concentration (EC 50 )were 4.44 μg·mL -1 and 0.32 μg·mL -1 respectively.While the half toxic concentration(TC 50 )of 911 to MT 4 cells was 7.78 mg·mL -1 and that to H 9 cells 7.47 mg·mL -1 .This finding confirmed of 911 a potent HIV1 inhibitor with low toxicity.更多还原