【摘要】 本文以鳗弧菌感染牙鲆幼鱼为动物模型，对我们制备的三株抗鳗弧菌单抗４Ａ６，３Ｂ２， ４Ｅ１２， ３Ｅ７， ３Ａ４的免疫保护效果进行了研究，结果表明： ４Ａ６， ３Ｂ２和４Ｅ１２具有明显提高受５ＬＤ５０鳗弧菌感染的牙鲆存活率的作用，同时它们还可明显延长受大剂量鳗弧菌（１０ＬＤ５０）感染的牙鲆的平均存活时间。提示： ４Ａ６， ３Ｂ２和４Ｅ１２具有中和或减弱鳗弧菌毒性的作用。更多还原

【Abstract】 The protective properties of monoclonal antibodies (mAbs) against V. anguillarum were studied in experimental flounder paralichthys olivaceus. The results showed that: (l) the survival rate of flounder challenged with 5LD50 of V. anguillarum was significantly higher in 4A6, 3B2,and 4E12 groups than in the control group (P<0.01). (2) 4A6, 3B2 and 4E12 mAbs were effective in extending the mean time of survival of ’flounders challenged with 10LD50 of V anguillarum. These results indicated that 4A6, 3B2 and 4E12 mAbs had the ability to neutralize the pathological effects of V. anguillarum.更多还原