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CIK细胞与LAK细胞对H-22腹水瘤的抑瘤作用

Anti-tumor activity of CIK cells and LAK cells on the mice bearing H-22 tumor in vivo

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【作者】 任欢邢淑贤周贵生王立荣田景先李殿俊

【Author】 REN Huan, XING Shu xian, ZHOU Gui sheng, et al (Department of Immunology, Harbin Medical University, Harbin 150086,China)

【机构】 哈尔滨医科大学免疫学教研室!黑龙江哈尔滨150086哈尔滨医科大学免疫学教研?

【摘要】 目的 观察CIK细胞及LAK细胞对H 2 2荷瘤鼠的抗肿瘤作用。方法 建立H - 2 2荷瘤鼠肿瘤动物模型 ,静脉输入CIK细胞 3周做抗肿瘤治疗 ,同时设LAK对照 ;用同位素法检测经治疗后荷瘤鼠T细胞增殖及NK细胞毒活性。结果 CIK细胞对H 2 2荷瘤鼠的抗肿瘤作用显著强于LAK细胞 (抑瘤率分别是 5 4%vs2 7% ) ;并且CIK疗法的抗肿瘤作用可能与荷瘤鼠T细胞增殖活性增高有关。结论 CIK细胞对H 2 2荷瘤鼠的体内抗肿瘤作用显著强于LAK细胞

【Abstract】 Objective To evaluate the anti tumor activity of CIK (cytokine induced killer) cells on Kunming mice bearing H 22 tumor in vivo .Methods CIK cells were injected intravenously into the mice bearing H 22 tumor for 3 weeks and compared with LAK controls in the same time. Results CIK cells had significantly anti tumor effect (the median inhibitory rate was 54%) which was much higher than that of LAK cells(the median inhibitory rate was 27.1%); and the later experiment suggested that CIK therapy was correlated with inducing the proliferation of the mice spleen T cells other than the NK cytolytic activity. Conclusion CIK therapy was more effective on mice bearing H 22 tumor in vivo than that of LAK.

【关键词】 CIK细胞H-22抗肿瘤作用
【Key words】 CIKH 22anti tumoreffect
【基金】 黑龙江省教委科研基金! ( 970 0 0 12 )
  • 【文献出处】 哈尔滨医科大学学报 ,JOURNAL OF HARBIN MEDICAL UNIVERSITY , 编辑部邮箱 ,2000年02期
  • 【分类号】R730.3
  • 【被引频次】17
  • 【下载频次】114
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