【摘要】 目的　研究胃癌组织增殖细胞核抗原 (PCNA)表达意义。方法　应用免疫组织化学方法检测PCNA在 98例胃癌标本中的表达。结果　在 98例胃癌标本中 ,PCNA标记指数 (PCNALI)在 15 85 %～ 82 12 %之间 ,平均为5 2 17%± 11 4 6%。PCNALI在低分化胃癌 (直径 >5cm ,有淋巴结和其他脏器转移 )中的表达远高于高分化胃癌 (直径 <5cm ,无淋巴转移 )。以 5 0 %为界限 ,PCNALI>5 0 %者生存期短 ,5年生存率低。结论　PCNA对胃癌的诊断、分期、预后及治疗有重要价值更多还原

【Abstract】 Objective To study the clinical significance of expression of proliferating cell nuclear antigen (PCNA) in gastric carcinoma tissues.Methods The expression of 98 gastric carcinoma was studied by means of immunohistochemical technique.Results The proliferating cell nuclear antigen labeling index (PCNA LI) was between 15.85% and 82.12% in 98 cases of gastric carcinoma.The PCNA LI was significantly higher in the cases of poorly differentiated(diameter≥5 centimeters,with lymph node and other organs metastases) than those well (differentiated,diameter<5 centimeters,without lymph node metastases).Patients with PCNA LI> 50% correlated to a decreased survival.Conclusion The determination of PCNA may be useful for diagnosis,clinical staging,prognosis and treatment of gastric carcinoma.更多还原