【摘要】 目的 :建立眼用诺氟沙星毫微粒包封率和载药量的测定方法。方法 :采用紫外分光光度法测定诺氟沙星聚氰基丙烯酸正丁酯毫微粒上清液中药物含量 ,进而计算其包封率和载药量。结果 :紫外检测波长 2 75nm ,线性范围 2 .0～ 7.0 μg .ml 1 ,平均回收率 96 .77%± 0 .93 %。结论 :该法操作简便、可靠 ,重复性好 ,共存组分无干扰更多还原

【Abstract】 OBJECTIVE:To establish the assay of enbedding ratio(ER%) and drug loading(DL%) of NFLX PBCA NP. METHODS:NFLX PBCA NP was determined by the spectrophotometry and calculated the ER% and DL%. RESULTS:The wavelength was 275 nm,the standard curve was linear within 2.0 7.0 μg·ml 1 ,the average recovery was 96.77%. RSD =0.93% Between day,the RSD was less than 1.00%. CONCLUSION:The method is simple and reliable.更多还原