【摘要】 为探讨高血压病肝阳上亢证与酪氨酸羟化酶基因 (TH )多态性的相关性 ,采用西医辨病和中医辨证方法选择研究对象 ,用 Southern Blot分析了肝阳上亢证、肝肾阴虚证和健康人 TH基因多态性 ,并测定了血浆去甲肾上腺素 (NE)和肾上腺素 (E)。结果表明 :高血压病肝阳上亢证患者血浆 NE、E含量明显高于健康人组和肝肾阴虚证组 (P<0 .0 5 ) ,高血压病肝阳上亢证 TH基因有显著扩增 (P<0 .0 5 )。提示高血压病肝阳上亢证的形成可能与 TH基因扩增有关更多还原

【Abstract】 Objective:To investigate the characteristic tyrosine hydroxylase polymorphism of human hypertension with hyperactive Liver-yang.Method:Southern Blot was used to test the tyrosine hydroxylase gene polymorphism of human hypertension with hyperactive Liver-yang and measure the norepinehrine and epinehrine in blood.Results:The norepinehrine and epinehrine of human hypertension with hyperactive Liver-yang were higher than those of the normal group and Liver-kidney ying deficiency group(P<0 05).There was tyrosine hydroxylase gene polymorphism in human hypertension with hyperactive Live-yang(P<0 05).Conclusion:The development of the hyperactivity of the Liver yang is linked with tyrosine hydroxylase polymorphism.更多还原