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蝎毒复合胶囊合并放疗治疗中晚期肿瘤患者的临床研究

Clinical treatment of the tumor in medium and advanced stage with capsules of antineoplastic factor of scorpion venom combined with radiotherapy

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【作者】 杨志华肖桂元杨卓平郭进武孔天翰

【Author】 YANG Zhihua 1) , XIAO Guiyuan 2) ,YANG Zhuoping 2) , GUO Jinwu 3) ,KONG Tianhan 4) 1)Department of Tumor,Zhanjiang Central People’s Hospital,Zhanjiang 524037 2)Zhanjiang Institute of Clinical Medicine, Zhanjiang 524037 3)Departmen

【机构】 湛江市中心人民医院肿瘤科!湛江524037湛江市临床医学研究所!湛江524037洛阳高等医学专科学校化学教研室!洛阳4710034河南医科大学生物毒素中心!郑州450052

【摘要】 目的 :探讨蝎毒复合胶囊 (capsulesofantineoplasticfactorofscorpionvenom ,CAFSV)配合放疗治疗中晚期恶性肿瘤患者的疗效。方法 :84例同期中晚期恶性肿瘤患者 ,随机分为 2组 ,治疗组 41例 ,对照组 43例。治疗组采用CAFSV口服 ,3次 /d ,2粒 /次 ,连续用药 7周 ,配合常规放疗 ;对照组单纯放疗。观察 2组患者在治疗前后的生存质量、T细胞亚群的变化及肿瘤退缩情况。结果 :治疗组的生存质量卡氏评分、免疫功能提高 ,肿瘤明显缩小 ,与对照组比较 ,差异有显著性 (P <0 .0 5 )。结论 :CAFSV具有抑制肿瘤生长 ,提高放疗疗效作用

【Abstract】 Aim: In order to observe the effect of clinical treatment of the tumor in medium and advanced stage with capsules of antineoplastic factor of scorpion venom(CAFSV) combined with radiotherapy. Methods: 84 patients with medium and advanced tumor in the same period were divided into 2 groups, 41 in treated group and 43 in control group. Combined with ordinary radiotherapy, the patients in treated group were given CAFSV orally for seven weeks, 2 pills once and 3 times each day. Those in control group were treated by radiotheraphy merely. It was observed on quality of life (QOL), changes of immune system function and reduction of tumors after treatments. Results: The karnofsky and immune system function were improved, and tumors reduced obviously in treated group. Compared with control group, it was significantly different( P <0.05). Conclusion : CAFSV possesses the inhibitory effect on tumor growth and can enhance effects of radiotherapy.

【关键词】 蝎毒肿瘤放射治疗
【Key words】 scorpion venomtumorradiotherapy
【基金】 河南省“九五”科技攻关项目! 95 12 0 0 10 2
  • 【文献出处】 河南医科大学学报 ,JOURNA OF HENAN MEDICAL UNIVERSITY , 编辑部邮箱 ,2000年04期
  • 【分类号】R730.5
  • 【被引频次】16
  • 【下载频次】71
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