【摘要】 目的　小儿血管瘤组织中是否存在雌激素受体(ER)目前尚无定论,本研究旨在探讨小儿血管瘤组织中究竟有无ER的存在,为临床治疗提供理论依据。方法　利用免疫组织化学法对22例小儿(年龄<14岁)血管瘤,12例成人血管瘤标本的ER进行检测,另取15例正常皮肤作为对照。结果　22例小儿血管瘤瘤体中ER(+)者17例,ER(-)者5例,在12例成人血管瘤瘤体中ER(+)者3例,ER(-)者9例(χ2=876　P<001)。15例正常皮肤对照ER均(-)。结论　小儿血管瘤组织中存在ER,且与成人血管瘤病例相比有显著性差异,雌激素是通过与血管瘤组织中ER的结合而发挥其生物学效应。成人血管瘤组织中ER阳性率偏低,雌激素也可以直接引起微血管扩张,故推测雌激素是可能直接作用于血管瘤组织而不是通过受体起作用。更多还原

【Abstract】 Objective To inverstigate whether estrogen receptor (ER) is present in children hemangioma tissues, and provide theoretical basis for clinical treatment. Methods: The specimens from 22 children (less than 14 years old) and 12 adults with hemangioma were studied with immunohistochemical techniques. The 15 normal skin specimens served as control.Results Of 22 children, ER(+) were found in 17, ER(-), in 5; of 12 adults, ER(+) were seen in 3, ER(-) in 9(χ 2=8 76 P <0 01); of 15 normal skin, all were ER(-).Conclusions ER are present in children’s hemangioma tissues, as compared with adults, there are significant difference. The positive rate of hemangioma tissues in adults is low, estrogen may directly cause microangium to expand. The results suggest that estrogen may directly act on hemangioma,not through receptors更多还原