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¹⁸⁸Re—AEDP在小鼠中的生物分布及其与载体的依赖关系

Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier

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【Author】 LI Qingnuan, ZHANG Xiaodong, SHENG Rong, MING Xiaofeng XU Jianying, HU Weiqing, LI Wenxin (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) (Pharmaceutical College Zhe jiang University, Hangzhou 310031) (Shangha

【机构】中国科学院上海原子核研究所!上海201800；浙江大学湖滨校区药学院!杭州310031；上海科兴药业公司!上海201800；

【摘要】用１８８Ｗ／１８８Ｒｅ发生器淋洗得到的１８８Ｒｅ示踪剂分别制备了无载体和有载体的１８８Ｒｅ－ＡＥＤＰ（１－氨基－亚乙基－１，１－二膦酸），研究了这两种标记化合物在小鼠体内的分布，并讨论了载体对１８８Ｒｅ－ＡＥＤＰ生物分布的可能影响。实验结果指出：有载体的１８８Ｒｅ－ＡＥＤＰ有更高的骨摄取率和Ｔ／ＮＴ比，并且血液清除快，因而是一个有潜在价值的骨疼痛治疗剂。更多还原

【Abstract】 Carrier-free 188Re- and carrier-added 188Re-AEDP (1-amino-ethylene diphosphonic acid) were synthesized by using 188Re tracer eluted from 188W/188Re generator. The distributions of both 188Re-labelled compounds in rats were measured and the dependence of their biodistribution on the rhenium carrier was studied. The results showed much higher skeletal uptake, T/NT and more rapid blood clearance when using carrier-added 188Re. It was found that carrier has effect on the skeletal uptake of 188Re-AEDP. Thus 188Re-AEDP is a potential radiopharmaceutical which may be therapeutically beneficial to bone metastases.更多还原