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32P-玻璃微球介入治疗肝细胞肝癌的临床初步应用

Preliminary clinical application of phosphorus-32 glass microspheres in interventional treating hepatocellular carcinoma

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【作者】 刘璐腾皋军姜藻何士诚谢松林吴联生宋副军郭金和方文赵成桂黄文旵

【Author】 LIU Lu1; TENG Gaojun2; JIANG Zao2; HE Shicheng2; XIE Songlin3; WU Liansheng4; SONG Fujun5; GUO Jinhe2; FANG Wen2; ZHAO Chenggui2; HUANG Wenchan6 1 (Nanjing Railway Medical College, Nanjing 210009) 2 (Affiliated Hospital, Nanjing Railway Medical College,

【机构】 南京铁道医学院科研所!南京210009南京铁道医学院附属医院!南京210009南京空军四五四医院!南京210002南化医院!南京210048南京市肿瘤医院!南京210003南京铁道医?

【摘要】 采用 Seldingers穿刺法,导管超选择至肝固有动脉以远,灌注32P-玻璃微球(32P-GMS),对79例肝细胞肝癌(HCC)实施了99次内照射介入治疗。结果表明,A方案半年及1、2、3年生存率分别为100%、96.7%、56.7%和43.3%;B方案分别为97.9%、918%、61.2%和51.0%。经治后的中位生存时间为585天。多因素分析显示:肝功能、肿瘤大小、临床类型及32P-GMS在瘤体内积聚情况是影响生存率的预后因素。说明32P-GMS是一种安全、有效的肝癌治疗方法。

【Abstract】 To evaluate the therapeutic effect of phosphorus-32 glass microsphere (32P-GMS) on hepatocellular carcinoma. By Seldinger’s procedure, super-selective catheterization was performed to the distal end of proper hepatic artery for instilling 32p-GMS. Ninety-nine times of interventional internal irradiation were accomplished in 79 cases of hepatocellular carcinoma. Results shows that surviving rates in A or B regimen at half year, 1, 2 and 3 years were 100%, 96.7%, 56.7% and 43.3% or 97.9%, 91.8%, 61.2% and 51.0% respectively. The median surviving time after therapy was 585 days single multifactorial analysis revealed liver function, tumor size, clinical typing and accumulation of 32P-GMS in the tumor mass and the therapeutic regime were the prognostic factors influencing the surviving rate of the patient. Conclusion:32P-GMS is a safe, effective and economic method for the therapeutic measure in treating hepatocellular carcinoma.

【基金】 江苏省科委资助!BJ93077;国家863资助!No.715-002-0200
  • 【分类号】R735.7
  • 【被引频次】15
  • 【下载频次】96
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