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32P-玻璃微球介入治疗肝细胞肝癌的临床初步应用
Preliminary clinical application of phosphorus-32 glass microspheres in interventional treating hepatocellular carcinoma
【摘要】 采用 Seldingers穿刺法,导管超选择至肝固有动脉以远,灌注32P-玻璃微球(32P-GMS),对79例肝细胞肝癌(HCC)实施了99次内照射介入治疗。结果表明,A方案半年及1、2、3年生存率分别为100%、96.7%、56.7%和43.3%;B方案分别为97.9%、918%、61.2%和51.0%。经治后的中位生存时间为585天。多因素分析显示:肝功能、肿瘤大小、临床类型及32P-GMS在瘤体内积聚情况是影响生存率的预后因素。说明32P-GMS是一种安全、有效的肝癌治疗方法。
【Abstract】 To evaluate the therapeutic effect of phosphorus-32 glass microsphere (32P-GMS) on hepatocellular carcinoma. By Seldinger’s procedure, super-selective catheterization was performed to the distal end of proper hepatic artery for instilling 32p-GMS. Ninety-nine times of interventional internal irradiation were accomplished in 79 cases of hepatocellular carcinoma. Results shows that surviving rates in A or B regimen at half year, 1, 2 and 3 years were 100%, 96.7%, 56.7% and 43.3% or 97.9%, 91.8%, 61.2% and 51.0% respectively. The median surviving time after therapy was 585 days single multifactorial analysis revealed liver function, tumor size, clinical typing and accumulation of 32P-GMS in the tumor mass and the therapeutic regime were the prognostic factors influencing the surviving rate of the patient. Conclusion:32P-GMS is a safe, effective and economic method for the therapeutic measure in treating hepatocellular carcinoma.
【Key words】 Phosphorus-32 glass microspheres; Radioactive medicine; Internal irradiation interventional therapy; Liver carcinoma;
- 【文献出处】 核技术 ,NUCLEAR TECHNIQUES , 编辑部邮箱 ,2000年05期
- 【分类号】R735.7
- 【被引频次】15
- 【下载频次】96