【摘要】 目的　评估ＶＡＤ方案和ＭＰ方案治疗初治的多发性骨髓瘤的疗效。方法　２１例初治的多发性骨髓瘤患者随机分为两组：ＶＡＤ治疗组１１例，ＭＰ治疗组１０例，两组均有部分病例合并用ａ－干扰素。结果 ＶＡＤ治疗组有效率８１％（９／１１），ＭＰ治疗组有效率 ６０％（６／１０），ＶＡＤ治疗组疗效高于 ＭＰ治疗组（Ｐ＞０． ０５），联合ａ－干扰素治疗患者均为有效病例。结论　对于初治的多发性骨髓瘤患者ＭＰ方案和ＶＡＤ方案均可使用，以现代强化疗的治疗观点，ＶＡＤ更有利于提高缓解率，尤其是对于肾功能不全、准备行大剂量化疗或移植干细胞来巩固缓解者，应首选ＶＡＤ方案治疗。用 ａ－干扰素联合化疗可提高疗效。更多还原

【Abstract】 Objective To compare the therapeutic effect between VAD and MP regimen in initial untreated patients with multiple myeloma(MM). Methods Twenty-one patients were devided randomly into two groups. Eleven patients received VAD and the other ten patients received MP regimen. Simultaneously interferon-a was received in some patients. Results The effective rate were 81% in patients received VAD,and 60% in patients received MP respectively(P>0. 05). All the patients comdined use of interferon allowed effective response. Conclusion The initial untreated patients with MM can be treated with VAD or MP regimen. VAD can increase the remission rate. Interferon-a injection added simultaneously can improve therapeutic effect.更多还原