【摘要】 目的研究HDV重叠HBV感染对乙型肝炎患者病情和血清学指标的影响。方法采用ELISA法检测HDV血清标志HDAg、抗HD、抗HDIgM和HBV血清标志HBsAg、抗HBs、HBeAg、抗HBe、抗HBc、抗HBcIgM ,PCR法检测HBVDNA。结果 316例乙型病毒性肝炎中 6 0例重叠HDV感染 ,重叠感染率为 18.98% ;CH和FH组HDV感染率显著高于AH ,FH组HDV复制指标阳性率显著高于CH及AH组 ;HDVM阳性组HBV复制指标阳性率显著低于HDVM阴性组。结论本组乙型肝炎患者HDV重叠感染率为 18.98% ;HDV感染与病情慢性化和重症化有关 ;HDV感染抑制HBV的复制 ;HDAg、抗HDIgM可以间接反映HDV在体内的复制情况及传染性。更多还原

【Abstract】 ObjectiveTo study the influence of HDV superinfection on the clinical features and HBV serum markers in patients with hepatitis B. MethodsHDV serum markers (HDAg,antiHD,antiHDIgM)and HBV serum markers (HBsAg,antiHBs, HBeAg,antiHBe,antiHBc,antiHBcIgM) were examined by ELISA method, and HBVDNA was examined by PCR method. Results60( 18.98 % ) cases were superinfected with HDV among 316 patients with hepatitis B. The infectious rate of HDV in group CH and group FH was significantly higher than that in group AH.The positive rate of HDV reproductive markers in group FH was also higher than that in group CH and group AH. The positive rate of HBV reproductive markers in HDVM positive group was significantly lower than that in HDVM negative group. ConclusionThe study shows that HDV superinfectious rate was 18.98 %,and there was correlation between HDV superinfection and chronic and severe hepatic damage, and HDV superinfection could suppress HBV reproduction, and HDAg,antiHDIgM reflect indirectly HDV reproduction and infectivity in the patients with hepatitis B.更多还原