【摘要】 目的 探讨胶质母细胞瘤（ｇｌｉｏｂｌａｓｔｏｍａｓ，ＧＢＭｓ） 中ｐ１６ 、Ｒｂ 基因表达水平的异常及其与细胞增殖活性之间的关系。方法 应用流式细胞仪检测３２ 例胶质母细胞瘤标本中ｐ１６ 、Ｒｂ 基因蛋白表达的相对含量。结果 胶质母细胞瘤中ｐ１６、Ｒｂ 基因蛋白表达量较正常脑组织降低，二者的异常可使细胞发生过度增殖。结论ｐ１６ 基因和Ｒｂ 基因表达活性降低是胶质母细胞瘤发生发展的重要因素之一。更多还原

【Abstract】 ObjectiveTo explore the abnormalities of expression of p16,Rb genes and the relationship between these abnormalities and the cell proliferation in glioblastomas (GBMs).MethodsThe expression of p16 gene and Rb gene was measured by flow cytometry in 32 cases of GBMs.ResultsThe amounts of the expression of p16 gene and Rb gene in GBMs were lower than those in normal brains.These abnormalities may cause over proliferation of GBMs cells.ConclusionThe abnormalities of expression p16 gene and Rb gene are the important factors for the development of GBMs.更多还原