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胶质母细胞瘤中p16、Rb基因表达水平与细胞增殖活性相互关系的研究

RELATIONSHIP BETWEEN EXPRESSION OF p16,Rb GENES AND CELL PROLIFERATION IN GLIOBLASTOMAS

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【作者】 李文玲张荣勋李春仲赵文清张学新

【Author】 Li Wenling Zhang Rongxun Li Chunzhong Zhao Wenqing Zhang Xuexing Department of Neurosurgery, the Fourth Hospital of Hebei Medical University (Shijiazhuang 050011)

【机构】 河北医科大学第四医院神经外科!石家庄050011河北医科大学!石家庄050011

【摘要】 目的 探讨胶质母细胞瘤(glioblastomas,GBMs) 中p16 、Rb 基因表达水平的异常及其与细胞增殖活性之间的关系。方法 应用流式细胞仪检测32 例胶质母细胞瘤标本中p16 、Rb 基因蛋白表达的相对含量。结果 胶质母细胞瘤中p16、Rb 基因蛋白表达量较正常脑组织降低,二者的异常可使细胞发生过度增殖。结论p16 基因和Rb 基因表达活性降低是胶质母细胞瘤发生发展的重要因素之一。

【Abstract】 ObjectiveTo explore the abnormalities of expression of p16,Rb genes and the relationship between these abnormalities and the cell proliferation in glioblastomas (GBMs).MethodsThe expression of p16 gene and Rb gene was measured by flow cytometry in 32 cases of GBMs.ResultsThe amounts of the expression of p16 gene and Rb gene in GBMs were lower than those in normal brains.These abnormalities may cause over proliferation of GBMs cells.ConclusionThe abnormalities of expression p16 gene and Rb gene are the important factors for the development of GBMs.

  • 【文献出处】 河北医科大学学报 ,JOURNAL OF HEBEI MEDICAL UNIVERSITY , 编辑部邮箱 ,2000年01期
  • 【分类号】R730.23
  • 【下载频次】22
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