【摘要】 目的 :探讨长效避孕针醋酸甲孕酮 (DMPA)对中国妇女骨质代谢的影响。方法 :自愿使用 15 0mgDMPA避孕者 30人组成实验组 ,采用阴茎套避孕者 30人组成对照组。测定两组血清雌二醇 (E2 )、血清碱性磷酸酶 (AKP)、尿钙 /肌酐 (Ca/Cr)、尿羟脯氨酸 /肌酐 (Hyp/Cr)及非惯用臂桡尺骨超远端骨矿含量 (BMC)、骨矿密度 (BMD)。结果 :两组血清雌二醇、血清碱性磷酸酶、尿钙 /肌酐、尿羟脯氨酸 /肌酐差异无显著性 (P >0 .0 5 ) ,两组非惯用臂桡尺骨超远端骨矿含量、骨矿密度差异无显著性 (P >0 .0 5 )。结论 :使用DMPA避孕 1年对妇女骨质代谢无影响。更多还原

【Abstract】 Objective: To study the effect of depo medroxyprogesterone acetate(DMPA,Depo Genston)on bone metabolism in women.Methods: Sixty volunteers were divided into experimental group(n=30) and control group(n=30) randomly.The experimental group accepted 150 mg DMPA for contraception. The control group used condoms for contraception. Blood levels of E 2 and AKP,urine levels of Ca/Cr and Hyp/Cr were measured. BMC and BMD of ultradistal forearm were determined.Results: There was no significant difference in blood levels of E 2 and AKP, urine levels of Ca/Cr and Hyp/Cr(P>0.05).There was no significant difference in the BMC and BMD of ultradistal forearm(P>0.05). Conclusion: DMPA had no effect on bone metabolism after using it for one year.更多还原