【摘要】 探讨氯化血红素用β-环糊精包合后的溶解度和体外溶出度 ,溶解度采用离心法 ,将氯化血红素及包合物用水配成饱和溶液 ,取适量以 40 0 0 r· m in- 1 离心 ,然后按分光光度法测定含量 ;溶出度采用桨法 (中国药典二部二法 ) ,以人工肠液为溶出介质 ,用分光光度法测定氯化血红素的含量。结果显示氯化血红素用β-环糊精包合后 ,溶解度和体外溶出度均有显著提高 ,制得的包合物水溶性好 ,体外溶出快 ,制备工艺简单易行。进一步证实包合物制备方法的可行性 ,同时也为氯化血红素加工成各种剂型开辟良好的前景。更多还原

【Abstract】 The stady on the solubility and dissolution rates of hemin before and after being incuded by β cyclodextrin was reported in this paper Solubility and dissolution rates of hemin before and after being incuded by β cyclodextrin was detemined by centrifugal method and oar method repectively The hemin was determined by UV spectrophotometry The solubility and dissolution rates of hemin can be increased after being included by β cyclodextrin The solubility of inclusion complex of hemin is good in water,the preparation process is simple and convenient,this method is feasible At the same time,the prospect of a good was opened up a lot of preparation being processed更多还原