【摘要】 目的了解慢性肺心病Ｔ淋巴细胞亚群、ＮＫ细胞活性及红细胞免疫功能变化及临床意义。方法：测定３０例肺心病患者急性发作期和缓解期外周血Ｔ淋巴细胞亚群、ＮＫ细胞活性及红细胞免疫功能，并与２５例正常人对照。结果：肺心病患者急性发作期 ＣＤ３、 ＣＤ４、 ＣＤ４／ＣＩ３８比值、 Ｃ３ｂＲＲ及 ＮＫ细胞活性均明显低于正常人（Ｐ＜０．０１），ＣＤ８则明显高于正常人（Ｐ＜０．０１），肺心病伴明显缺氧和高碳酸血症者变化最明显。治疗缓解期上述指标均有不同程度的恢复，但与正常人相比仍有差异（Ｐ＜０．０５）。结论：肺心病病人存在原发性免疫功能障碍，测定Ｔ淋巴细胞亚群、ＮＫ细胞活性及红细胞免疫功能对了解肺心病病人免疫力、指导治疗有一定临床意义。更多还原

【Abstract】 Objective To evaluate the changes and clinical significance of T Lymphocyte, erythrocyte immuniza- tion and serum levels of immunoglobulin in patients with pulmonary heart disease. Methods The T lymphocyte, NK activity and erythrocyte immunization function of 30 patients with pulmonary heart disease in acute and remission stage and 25 normal subjects were determined. Results The CD3. CD4,CD4/CD8, C3bRR and activity of NK cell de- creased, CD8 increased significantly in acute stage of patients with. pulmonary heart disease (P<0.01). In remission stage all the changes recovered in different degree but were still abnormal. Conclusions There are primary functional disorders in patients with pulmonary heart disease. The determination of T lymphocyte, NK activity and erythrocyte immunization function in patients with pulmonary heart disease can realize the immunity of patients and direct the treatment.更多还原