【摘要】 探讨 P5 3、Bcl- 2、Bax蛋白在脑胶质瘤表达水平以及和细胞凋亡的相关性。方法 :采用免疫组化 S- P染色法检测 47例脑胶质瘤组织中 P5 3、Bcl- 2、Bax蛋白的表达情况。结果 :在 47例脑胶质瘤中 ,P5 3 、Bcl- 2、Bax蛋白的阳性率分别为 48.9% (2 3/4 7) ,5 7.4% (2 7/4 7) ,17.0 2 % (8/4 7) (P<0 .0 5 ) ;发现 GBM的 P5 3蛋白阳性水平要高于 AS;Bcl- 2蛋白阳性水平 AS组显著高于 GBM。结论 :P5 3、Bcl- 2蛋白的高水平表达以及 Bax蛋白低表达与脑胶质瘤细胞的凋亡过程受阻而增殖加速关系密切。更多还原

【Abstract】 Objective:To investigate expression of P 53 ,Bcl 2 and Bax proteins in human brain gliomas and explore the relations between these oncogene expression and apoptosis of tumor cell Method:We used immunohistochemical staining to detect 47 cases of gliomas with three monoclonal antibody against P 53 ,Bcl 2 and Bax proteins Results:Expression of P 53 ,Bcl 2 and Bax proteins were positive in 48 9%(23/47),57 4%(27/47),17 02%(8/47)respectively,the positive rate of Bax protein was significantly less than positive rate of P 53 ,Bcl 2 proteins;P 53 expression of glioblastoma multiply was higher than P 53 expression of astrocytoma,whereas most astrocytoma was positive bcl 2 protein Conclusion:High level expression of P 53 ,Bcl 2 proteins and low level expression of Bax protein were significantly related to inhibition of apoptosis in human brain gliomas更多还原