【摘要】 基于吸附动力学方程和吸附质量平衡方程，提出了叠合式平板亲和膜吸附生物分子的动力学模型，采用Ｃｒａｎｋ－Ｎｉｃｈｏｌｓｏｎ有限差分隐解法求解联立方程组，考察了弥散系数、进料浓度、吸附反应正向结合速率常数、膜厚、配基浓度以及流速对吸附穿透曲线的影响，并用溶质回收率和配基利用率两个参数对吸附穿透曲线的操作效果进行了定量的表征。用文献报导的实验结果对模型的验证表明，当无固次流出浓度小于０．４时，实测结果与模型预测结果比较接近；当无因次流出浓度大于０．４时，两值相距较远，模型预测的吸附饱和时间小于实测值。更多还原

【Abstract】 A kinetic model for biomolecules adsorption to stacked flat-sheet affinity membrane was formulated based on adsorption kinetic equation and mass balance. The model equations are solved by Crank-Nicholson implicit finite difference methods. The results obtained from model simulation show that the breakthrough is influenced by dispersion coefficient, feed concentration, forward direction rate constant, membrane thickness, ligand concentration and flow rate. Breakthrough profiles are quantitatively discussed in terms of protein recovery and ligand utilization ratio. The experimental data from literature were used for model correlation. The result shows that when the dimensionless concentration is less than 0.4, the model simulation is in fair agreement with the experimental data but when the dimensionless concentration is higher than 0.4, the deviation became larger, and the saturation time predicted by the model is less than the experimental value.更多还原