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长期低浓度铅暴露对人体微量元素的影响

Trace Elements and Lipid Peroxidation Changes in Workers with Longterm Exposed to Low-dose Lead

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【作者】 程怀民张宏永沈波李文燕程生英郭维新陈锦李跃平王季仁吴碧娟张碧珍罗柏友

【Author】 CHENG Huai-ming, ZHAN Hong-yong, SHEN Bo et al (Health and Anti-epidemic Station of Jinan Distict, Fuzhou 350014, China)

【机构】 晋安区卫生防疫站!福建福州350014,晋安区卫生防疫站!福建福州350014,福建医科大学卫生教研室,福建医科大学卫生教研室,福建医科大学卫生教研室,福州市职业病防治院,福

【摘要】 测定了15名长时间从事低剂量铅接触的女工血铅、铜、锌、铁、锰及铜锌超氧化物歧化酶(Cu-Zn SOD)活性、脂质过氧化产物二级降解物丙二醛(MDA)含量,并以同年龄组同地区非铅暴露人群作对照。结果显示:暴露组的血铅、铜、MDA含量高于对照组(P<0.05);而血锌、 Cu-Zn SOD活性低于对照组(P< 0.05);血 Mn、 Fe两组无明显差异( P> 0.05)。提示:长期接触低浓度铅可诱发体内脂质过氧化,同时引起微量元素含量改变。

【Abstract】 Lead and other trace elements copper, zinc, manganese, iron as well as Cu-Zn-superox- ide dismutase (Cu-Zn SOD) activity and MDA content in the blood of 15 women-workers who were exposed to low-dose lead during long time were determined. The result showed that compared with the control group, the average content of Pb, Cu and MDA in lead exposed group significantly increased(P< 0.05), while Zn content and SOD activity were lower. It sugguests that longterm expose to low-dose lead can cause blood lead increased, the disorder of lipid peroxidation and the relevant changes of trace elements content.

【关键词】 微量元素脂质过氧化
【Key words】 leadlipid perxiodationtrace elements
  • 【文献出处】 广东微量元素科学 ,TRACE ELEMENTS SCIENCE , 编辑部邮箱 ,2000年01期
  • 【分类号】R135
  • 【被引频次】8
  • 【下载频次】107
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