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NOS活性在大鼠不同脑区的研究

THE STUDY OF NITRIC OXIDE SYNTHASE ACTIVITY IN DIFFERENT AREAS OF RAT BRAIN

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【作者】 夏保芦张艳熊希凯

【Author】 Xia Baolu, Zhang Yan *, Xiong Xikai * (Department of Physiology, Wuhan Professional Medical College, Wuhan 430016, * Department of Anatomy, Tongji Medical University, Wuhan 430030, China)

【机构】 武汉市职工医学院生理学教研室!武汉430016同济医科大学人体解剖学教研室!430030

【摘要】 一氧化氮 (NO)作为神经递质或调质已经确定。一氧化氮合酶 (NOS)活性在大鼠不同脑区的定位是本文研究的重点。采用 NADPHd酶组织化学方法 ,对大鼠海马、脑干内 NOS的活性进行观察。结果显示 :海马 (CA1 ~ CA3区 ) NOS为阳性 (+)、其中 CA2 为强阳性 ( ) ;非脑神经核 (红核、黑质 )为中等阳性 ( ) ;而脑神经核 (动眼神经核、动眼神经副核、面神经核、展神经核 ) NOS为阳性 (+) ;脑桥网状结构为阳性 (+) ;缝核群为阳性 (+) ;第三脑室和第四脑室脉络丛为阳性 (+)。

【Abstract】 Nitric oxide has been confirmed as neurotransmitter or modulator. This paper mainly studied the activities of nitric oxide synthase (NOS) in different areas of rat brain. The activities of nitric oxide synthase in the rat hippocampus and brain stem were histochemically examined with NADPH diaphorase. The results showed that NOS positive neurons were present in the hippocampus (CA 1~CA 3) in which NOS strong positive neurons were in CA 2; NOS medium positive nucleus in the nuclei nervorum non cranialium (red nucleus、 substantia nigra); NOS positive neurons in the nuclei nervorum cranialium (oculomotor、 accessory oculomotor nucleus, facial nucleus, abducens nucleus); NOS positive nucleus in the pons reticular formation; NOS positive nucleus in the raphe nucleus and in the plexus chorioideus ventriculi quartic and plexus chorioideus ventriculi tertii.

  • 【文献出处】 中国组织化学与细胞化学杂志 ,CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY , 编辑部邮箱 ,2000年01期
  • 【分类号】R338
  • 【被引频次】6
  • 【下载频次】61
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